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Establish and characterize an acute HIV infection cohort in a Thai high risk population. This study has enrolled 57 of 75 patients with acute HIV infection (HIV antibody negative, nucleic acid positive) who will be followed for 4 years.  Investigations of the immune response and HIV subtypes/sequences in the peripheral blood, gut, genital secretions and central nervous system are done.  Subjects are offered 5 vs. 3-drug HAART under a separated protocol. The study is funded by the US Military HIV Research Program (MHRP) and by the US NIH (R21MH086341).  A parallel study to evaluate the use of therapeutic HIV vaccine in addition to HAART in controlling HIV viremia following treatment interruption in this acutely treated population is in development.

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