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A cohort observational study evaluating predictors, incidence and immunopathogenesis of immune reconstitution syndrome (IRIS) in HIV-1 infected patients with a CD4 count <100 cells/µL who are initiating antiretroviral therapy. This study is to characterize IRIS and investigate the pathogenesis and the outcomes of IRIS. The study will begin enrolment in 2012 at TRCARC and Bamrasnaradura Infectious Diseases Institute. The study is funded by the US NIH and the US MHRP.

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